Abstract:
Cutaneous drug reactions are the most common type of adverse drug
reactions. Adverse cutaneous drug reactions form 2-3% of the hospitalized patients. 2%
of these are potentially serious. This study aims to detect the drugs commonly implicated
in Steven Johnson Syndrome-Toxic Epidermal Necrosis (SJS-TEN).
Materials and Methods: A retrospective analysis was done in all patients admitted in
the last fi ve years in SDM hospital with the diagnosis of SJS-TEN.
Results: A total of 22 patients with SJS-TEN were studied. In 11 patients anti-epileptics
was the causal drug and in 7, anti-microbials was the causal drug. Recovery was
much faster in case of anti epileptics induced SJS-TEN as compared to that induced
by ofl oxacin.
Conclusion: SJS-TEN induced by ofl oxacin has a higher morbidity and mortality
compared to anti convulsants.
