Abstract:
Background: Tuberculosis (TB) is characterized by significant inflammation
leading to complications like pulmonary fibrosis, constrictive pericarditis, etc. Drugs
possessing anti-inflammatory activity can reduce the complications of infections
occurring due to inflammation and fibrosis. To study the effect of rifampicin, isoniazid
on acute and subacute models of inflammation in male Wistar rats.
Methods: The in vivo anti-inflammatory activity of rifampicin, isoniazid was studied
using acute (carrageenan paw edema) and sub-acute (cotton pellet granuloma and
histopathologic examination of grass pith) models of inflammation.
Results: Rifampicin and isoniazid used in the present study showed significant anti-
inflammatory activity in acute as well as subacute models of inflammation.
Conclusion: Rifampicin and isoniazid when administered to treat TB can reduce
complications of TB by virtue of its anti-inflammatory activity.
