Abstract:
Total Homocysteine (tHcy) levels are found to be significantly raised in patients
suffering from cardiovascular diseases. In Non insulin dependent diabetes mellitus
(NIDDM) cardiovascular disease (CVD) is one of the major macrovascular
complications. The present study was conducted on a Goan population with an
objective to evaluate the relation between the plasma tHcy in diabetic individuals with
and without CVD. The one year cross sectional study comprised of 180 subjects,
including 60 NIDDM individuals, 60 NIDDM individuals with CVD and 60 healthy
controls. Plasma concentrations of tHcy levels were measured by High performance
liquid chromatography (HPLC) in all study subjects. The data obtained was statistically
analysed using student unpaired‘t’ test and comparison between the groups was done
by analysis of variance. The tHcy levels were found to be significantly elevated in
NIDDM and also in NIDDM with CVD in Goan Population
