Abstract:
Objectives: We determine the significant relation of HDL
cholesterol and total cholesterol/HDL cholesterol between CETP
I405V genotypes and activity of CETP.
CETP is an essential for transfer of cholesterol ester to the liver
from peripheral tissues which facilitating its transfer to TG rich
VLDL. Reduction activity of CETP I405V may associate with
genotypes of CETP I405V. This study is undertaken to assess the
presence and impact of CETP I405V genotype in our population.
Materials and Methods: In this study 100 acute myocardial
infarction patients and 100 normal age & sex matched healthy
individuals were included. Serum Lipid profile was estimated by
using universal standard methods whereas CETP I405V genotype
was studied by ARMS PCR.
Result: There is presence of CETP 405Val genotype both in patient
as well as in control group. Results show that HDL cholesterol
(p<0.0001) and ratio of total cholesterol/HDL cholesterol are
significantly (p<0.0043) associated with Val/Val genotype. In
addition to that the CETP I405V genotype is associated with
inhibition of CETP activity with higher HDL-C level and decreased
total cholesterol/HDL cholesterol ratio.
Conclusion: Our results show that the CETP I405V genotypes
are very much significantly determinant of HDL cholesterol in
patients with CHD
