Abstract:
Background: Hypertension on a long‐term basis can cause target organ damage, especially
the central nervous system, which can affect cognition. It is known that difference between
simple and choice reaction time (RT) implies time required for cognition. Although delayed
RTs indicate involvement of cognition, they cannot quantify how much time is required
for cognition. Aim: Recording chronoscpic RT to quantify time required for cognition in
hypertensives and compare them with controls. Subjects and Methods: This is a hospital‐based
case–control study conducted (August 2010 to January 2011) on 118 subjects attending an
outpatient department using visual and whole body reaction timers having criteria of age and
hypertensive condition, compared with an equal number of age‐ and sex‐matched controls.
Statistical analysis was carried out by Independent t test and duration of hypertension was
correlated with whole body choice reaction time (WBCRT) C1 using Pearson’s correlation.
Predictive value of WBCRT C1 was calculated by using the receiver operating characteristic
curve. Results: The WBCRT C1 562.6 (108) ms was more delayed among hypertensives
compared with controls 523.5( 98.8) ms. There was no significant correlation between duration
of hypertension and WBCRT C1 (r = −0.064). The best cut‐off value for WBCRT C1when
predicting cognitive dysfunction in hypertensive patients was 538.5 ms (sensitivity 76.2%,
specificity 50%). Conclusions: WBCRT C1 can be a quantitative measurement of cognition.
It can be used as a screening tool to detect cognitive dysfunction.
