Abstract:
A ganglioneuroma is a very rare neoplasm in the gastrointestinal tract and a benign
neoplasm of sympathetic nervous system. They predominantly affect the colon and rectum
and are rare to arise in gall bladder. Gastrointestinal ganglioneuromas occur as rare isolated
(solitary) polypoid lesions or more commonly as ganglioneuromatous polyposis and diffuse
ganglioneuromatosis. Isolated polypoid lesions are clinically asymptomatic and incidentally
detected during endoscopy or surgery. We report a case of a 42-year-female who presented
clinically with features of chronic cholecystitis and was operated. There was no association of
any hereditary disease. Incidentally the cholecystectomy specimen showed a small sessile
polypoid lesion. Histopathological examination showed the lesion to be polypoid
ganglioneuroma arising in gall bladder. The isolated polypoid ganglioneuroma is invariably
benign. They do not have increased risk of von Recklinghausen’s disease or multiple
endocrine neoplasia IIB and show no evidence of recurrence with excellent prognosis after
total excision.
