Abstract:
Hypericum perforatum L. study is an herbal antidepressant, which acts by
convulsions. The present (HP) therefore aims at exploring the influence
inhibiting non-selectively, theand its interactions with commonly used
of HP on convulsions reuptake of neurotransmitters like norepinephrine
(NE), gamma amino butyric acid (GABA), dopamine (DA), serotoninHP,
anticonvulsants viz...phenytoin and clonazepam in Wistar rats. (5HT)
and glutamate. Though its antidepressant and anxiolytic activities werewell
phenytoin and clonazepam in their therapeutic equivalent doses are
documented, on convulsions induced by maximum its effect on convulsions.
evaluated there is a paucity of information about electroshock seizure
The present study therefore aims atisoniazid (INH).For the interaction on
(MES), pentylenetetrazol (PTZ) and exploring the influence of HP
convulsions and coadministration with phenytoin in MES studies and with
studies, HP was its interactions with commonly used anticonvulsants
viz...phenytoin and clonazepam studies. HLE, number of seizures, duration
clonazepam in PTZ and INH in Wistar rats. HP, phenytoin and clonazepam
in of seizure and time for onsetdosesrecovery from seizures were monitored. by
their therapeutic equivalent and were evaluated on convulsions induced
maximum electroshock the rats in MES pentylenetetrazol (PTZ) and isoniazid
HP failed to protect seizure (MES), studies and worsened the seizures
(INH).For by PTZ as well studies, HPalso reversed the protective effects of in
induced the interaction as INH. It was coadministration with phenytoin
MES studies in MES and of clonazepam in PTZ as INH studies. HLE, number
phenytoin and with clonazepam in PTZ as well and INH seizure models.
of The findings of the present study suggest for onset as well proconvulsant
seizures, duration of seizure and time that HP possesses as recovery from
seizures were might compromise the to protect the rats in MES studies and
activity and monitored. HP failed efficacy of anticonvulsant therapy, if
worsened the of the present study could be extrapolated to humans.reversed the
the findings seizures induced by PTZ as well as INH. It also
protective effects of phenytoin in MES and of clonazepam in PTZ and INH
seizure models. The findings of the present study Pentylenetetrazole; Maximum
Key words: Hypericum perforatum; Interaction; Isoniazid; suggest that HP possesses
proconvulsant
electroshock seizure.activity and might compromise the efficacy of anticonvulsant
therapy, if the findings of the present study could be extrapolated to humans.
