Abstract:
Iodination is the process of substitution or addition of iodine atoms on organic compounds. The iodine is
reactive with all the three major biochemical constituents namely proteins, lipids and carbohydrates. Present study
was done to know the relationship between iodine uptake and glycated hemoglobin (GlyHb) levels in patients with
diabetes mellitus.The study was carried out in 50 patients with diabetes mellitus with mean GlyHb of 10.4±2 gm%
and 25 healthy controls with mean GlyHb level of 5.5±0.5 gm%.The modified version of the colorimetric method
was employed for the assay of iodine uptake and Glyco Hb levels were measured by 501 auto analyzer. The data
was analyzed using SPSS version 10. Serum total iodine uptake was decreased significantly (p<0.001) in the
patients with diabetes mellitus compared to healthy controls. There was significant negative correlation (r= -0.942,
p<0.01) between glyHb and iodine uptake in diabetes mellitus patients. We found significant decrease in iodine
uptake in diabetes patients compared as to controls. This may be due to increased glycation of proteins induced by
hyperglycemia which may interfere in binding of iodine to proteins including hemoglobin. Significant negative
correlation between glyHb and iodine uptake can be due to decrease in the availability of iodine binding sites due
to alteration in the structure of proteins, which is possibly induced by glycation of proteins, associated with
diabetes mellitus. According to our study iodine uptake is decreased in patients with diabetes mellitus which may
be due to increased glycation of proteins.
