Abstract:
The present study was undertaken to investigate endothelial dysfunction as root
cause in pathogenesis of preeclampsia, which has not yet been clearly understood.
Elevated oxygen free radicals partially explain endothelial cell damage. Our aim is to
measure NO, LPO and uric acid levels as endothelial dysfunction markers in
preeclamptic women. Thirty preeclamptic women and thirty gestational age matched
normal pregnant women were included in the study. Mild and severe preeclampsia
cases were evaluated for serum MDA, NO and uric acid levels. Serum MDA and uric
acid levels were significantly raised in women with mild and severe preeclampsia
when compared with normal pregnancy. Progressive increase in MDA levels were
statistically significant with increased severity of disease from mild to severe.
Significant reduction in mean NO levels were observed in preeclampsia as
compared to normal pregnant women. We conclude decreased concentration of NO
observed that point towards endothelial dysfunction which may be due to oxidative
stress reflection as of MDA & uric acid.